Conolidine
Monoterpene indole alkaloid from Tabernaemontana divaricata studied as a candidate non-opioid analgesic; a small molecule, not a peptide.
Overview
Conolidine is a monoterpene indole alkaloid isolated from the plant Tabernaemontana divaricata (crepe jasmine), which has a history of use in some traditional medicine systems for pain. It is a small molecule, not a peptide.
In recent years it has attracted research attention as a candidate non-opioid analgesic and is also promoted commercially in supplement form; the commercial promotion outstrips the published clinical evidence.
Mechanism
Studies in rodent pain models report analgesic activity, and some reports indicate that the effect is not fully blocked by the opioid antagonist naloxone, suggesting mechanisms distinct from classical opioid-receptor activation. The precise molecular targets remain under investigation, with various receptor and ion-channel hypotheses proposed.
Dosing
No clinical dosing has been established. Published preclinical work administers the compound systemically in rodent pain models, with amounts scaled to body weight.
- Systemic administration in rodent pain models
- Doses in animal work are scaled to body weight
- Supplement products are not equivalent to the studied preparations and lack clinical data
Expected Effects
- Analgesic-like behavior reported in several rodent pain assays
- Proposed non-opioid mechanism of action under investigation
- No clinical efficacy data in humans have been published
Side Effects & Tolerability
Safety data are limited to animal studies and isolated traditional use; some animal assessments report an absence of classical opioid side effects, but human tolerability is unstudied. Supplement claims should not be read as clinical evidence.
Storage
As a research compound, store per supplier instructions, typically cool, dry, and protected from light.