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Home/Hormone & Reproductive/HMG (Human Menopausal Gonadotropin)

HMG (Human Menopausal Gonadotropin)

Purified urinary gonadotropin preparation (menotropin) containing FSH and LH activity; an established agent in fertility treatment.

Overview

Human menopausal gonadotropin (HMG), also known as menotropin, is a gonadotropin preparation purified from the urine of postmenopausal women that contains both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity. It has been used in reproductive medicine for decades to stimulate ovarian follicle development and, in men, to support spermatogenesis in hypogonadotropic hypogonadism. Pharmaceutical HMG is typically presented in vials standardized to 75 IU of FSH activity with 75 IU of LH activity.

Mechanism

HMG provides exogenous gonadotropins that act directly on the gonads, bypassing pituitary control. FSH drives ovarian follicle growth and, in men, supports Sertoli-cell function and early spermatogenesis, while LH (or the LH-like activity in HMG) stimulates steroidogenesis, which in men is completed by co-administered hCG.

Dosing

Clinical regimens are indication-specific and defined by fertility protocols and product labeling, with daily intramuscular or subcutaneous injections during controlled ovarian stimulation. Research or self-directed use should not rely on vendor listings; dosing belongs to licensed clinical practice.

Expected Effects

  • multiple follicle development in controlled ovarian stimulation
  • ovulation induction in anovulatory women as part of treatment protocols
  • stimulation of spermatogenesis in hypogonadotropic men when combined with hCG

Side Effects & Tolerability

Documented risks include ovarian hyperstimulation syndrome, multiple pregnancy, injection-site reactions, and, rarely, allergic responses. As a urinary-derived biologic, pharmaceutical HMG is manufactured under regulated quality controls; unregulated sources carry additional risks.

Storage

Pharmaceutical HMG is supplied as lyophilized powder with diluent and stored per the label, typically refrigerated, with reconstituted solutions used within the stated period.

Related peptides

Androstadienone Peptide AnalogsListing for peptide analogs of a steroid human chemosignal; no such compounds are described in the scientific literature.Feedback Inhibitor Peptides (FIP)Catalog category of peptides claimed to regulate endocrine feedback loops; no standardized compounds are established under this name.GnRH Agonist Analogs (Expanded)Catalog grouping for clinically established GnRH agonist peptide drugs such as leuprolide, goserelin, triptorelin, and buserelin.GonadorelinSynthetic gonadotropin-releasing hormone (GnRH) decapeptide, the hypothalamic trigger for LH and FSH secretion; used in diagnostics and research.HCG (Human Chorionic Gonadotropin)Placental glycoprotein hormone with LH-like activity; an established clinical agent in fertility treatment and gonadotropin research.Hypothalamic-Pituitary Master Regulator AnalogsPromotional catalog category combining axis-level terms; no fixed composition or peer-reviewed identity.