Bromelain Peptide Complex
Mixture of proteolytic enzymes from pineapple stems studied as a supplement for inflammation and edema; an enzyme preparation, not a peptide.
Overview
Bromelain is a mixture of proteolytic (cysteine protease) enzymes extracted from pineapple stems and fruit. Despite the catalog name Bromelain Peptide Complex, it is an enzyme preparation rather than a peptide.
It has a long history of use as a dietary supplement and has been studied for anti-inflammatory, anti-edema, and digestive-support applications.
Mechanism
Bromelain's proposed effects are attributed largely to its protease activity, which can cleave proteins relevant to inflammation; modulation of inflammatory mediators and fibrinolytic-type actions have been discussed in the literature. Oral absorption of intact active enzymes is limited and debated.
Dosing
As a supplement, bromelain is taken orally, with or between meals depending on the intended use. Enzyme activity is expressed in standardized units (such as GDU or mCU per gram), and products vary widely in potency.
- Oral supplement use is typical; formulations are standardized by protease activity units
- Amounts used in studies vary widely, making direct comparison difficult
- Enteric-coated and high-potency preparations are marketed to resist gastric degradation
Expected Effects
- Reduced swelling and bruising reported in some surgical and dental studies
- Mild symptom relief in some upper-respiratory trials when combined with other enzymes
- Digestive-aid use is traditional, but the evidence base is limited
Side Effects & Tolerability
Generally well tolerated; gastrointestinal upset and allergic reactions can occur. Because of its fibrinolytic-type activity, caution is commonly advised in people taking anticoagulant or antiplatelet medication, though clinically significant interactions are not well documented.
Storage
Store in a cool, dry place. Some preparations are moisture- and heat-sensitive; follow the product label.