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Home/Weight Loss & Metabolic/C-Peptide Analogs

C-Peptide Analogs

Synthetic peptides related to the proinsulin connecting peptide, whose native form has been studied as an adjunct in type 1 diabetes; analogs are undocumented.

Overview

C-peptide is the 31-amino-acid connecting peptide of proinsulin, released in equimolar amounts with insulin. Once regarded as biologically inert, it is now recognized to exert physiological effects, particularly on the microvasculature and peripheral nerves, and it has been studied as an adjunct in type 1 diabetes.

This catalog listing groups synthetic peptides related to C-peptide. Most published work has used native human C-peptide; the specific analogs supplied by vendors are generally not described in the scientific literature.

Mechanism

C-peptide has been reported to bind cell-surface binding sites and to activate signaling pathways that stimulate endothelial nitric oxide synthase (eNOS) and Na+/K+-ATPase, countering some hyperglycemia-associated microvascular dysfunction.

Dosing

Clinical studies of native C-peptide in type 1 diabetes used continuous subcutaneous infusion or multiple daily injections at doses intended to approximate physiological levels. No dosing exists for the uncharacterized analog products in this category.

  • Physiological-replacement regimens in type 1 diabetes studies used subcutaneous delivery
  • Native C-peptide dosing is the only published basis; analog products lack data
  • No standard protocol exists for research-vendor C-peptide analogs

Expected Effects

  • Improved nerve conduction and autonomic function reported in small type 1 diabetes studies
  • Reduced urinary albumin excretion reported in some trials
  • Results come from small studies and remain debated

Side Effects & Tolerability

Native C-peptide administered at physiological doses has generally been well tolerated in clinical studies. No safety information exists for the uncharacterized analog products.

Storage

Store lyophilized peptides frozen, desiccated, and protected from light; follow supplier reconstitution guidance.

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