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Dihexa

Synthetic small-molecule compound developed in academic research on HGF/c-Met signaling; reported to improve memory in rodent models. Not a peptide.

Overview

Dihexa is a synthetic small-molecule compound (not a peptide) developed in academic research on the hepatocyte growth factor (HGF)/c-Met signaling system. It was identified as a compound that potentiates HGF signaling at the c-Met receptor and has been studied mainly for effects on synaptic function and memory.

Published work, conducted largely in rodent models, reports improvements in cognitive performance in aged or pharmacologically impaired animals. Human data are not available.

Mechanism

Dihexa is described as an HGF potentiator that enhances c-Met activation; in the brain, HGF/c-Met signaling has been linked to synapse formation and plasticity. Studies report increased dendritic spine density and synaptic connectivity in treated animals, proposed to underlie the improved memory performance.

Dosing

All dosing information comes from animal research. In rodent studies, dihexa is typically administered systemically over multi-day treatment periods, with amounts scaled to body weight.

  • Systemic administration in rodent studies
  • Multi-day treatment periods in memory-task protocols
  • No human dosing has been established

Expected Effects

  • Improved performance on memory tasks in aged rats reported in published studies
  • Reversal of pharmacologically induced memory impairment reported in some work
  • Increased markers of synaptic connectivity in treated animals
  • Effects in humans are unstudied

Side Effects & Tolerability

Tolerability data are limited to short-term rodent studies. Human safety, pharmacokinetics, and long-term effects are unknown.

Storage

Store the compound per supplier instructions, typically dry, cool, and protected from light.

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