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Home/Recovery & Healing/Pal-GHK (Palmitoyl-GHK)

Pal-GHK (Palmitoyl-GHK)

A palmitoylated derivative of the tripeptide GHK, used as a collagen-supporting ingredient in topical cosmetic formulations.

Overview

Pal-GHK (palmitoyl tripeptide-1) is a lipophilic derivative of the naturally occurring tripeptide glycyl-histidyl-lysine (GHK), in which a palmitic acid chain is attached to improve skin penetration. It is a cosmetic ingredient rather than a drug, and it appears in topical formulations marketed for skin aging and support of dermal matrix.

Mechanism

The GHK moiety carries the proposed signaling activity; in cell-culture studies, GHK-related peptides have been associated with increased production of collagen and other matrix molecules by dermal fibroblasts. Palmitoylation is intended to anchor the peptide within skin layers and enhance its delivery into the epidermis and dermis after topical application.

Expected Effects

  • Positioned in cosmetics as a collagen-supporting, anti-wrinkle ingredient
  • In vitro work reports stimulation of collagen synthesis markers in fibroblast cultures
  • Clinical evidence is largely limited to formulation-level cosmetic studies

Side Effects & Tolerability

Because it is intended for topical cosmetic use, systemic safety data are minimal. The main tolerability consideration is local skin irritation or sensitization, which standard testing during formulation development is designed to detect.

Storage

Raw peptide should be stored cold and desiccated, protected from light and moisture. Finished cosmetic formulations follow the stability guidance of the manufacturer.

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