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Home/Weight Loss & Metabolic/SLU-PP-332

SLU-PP-332

A synthetic small-molecule agonist of estrogen-related receptors, not a peptide; reported as an exercise mimetic in mice.

Overview

SLU-PP-332 is a synthetic small-molecule agonist of the estrogen-related receptors (ERRs), principally ERR-alpha, developed at Saint Louis University. It is not a peptide. It has been reported to act as an exercise mimetic, increasing fatigue resistance and oxidative metabolism in preclinical mouse studies.

Mechanism

ERR-alpha is a nuclear receptor that regulates genes for oxidative metabolism and mitochondrial biogenesis. SLU-PP-332 binding activates these transcriptional programs, increasing the expression of metabolic and mitochondrial genes in skeletal muscle, which underlies the reported endurance effects.

Expected Effects

  • Increased running endurance and fatigue resistance in mice
  • Upregulation of oxidative-metabolism and mitochondrial genes in muscle
  • Proposed applications in metabolic and muscle-wasting conditions remain preclinical

Side Effects & Tolerability

Safety data are limited to animal studies, and no human trials have been reported. Effects of ERR activation in other tissues are incompletely mapped.

Storage

Store the compound as supplied, protected from light and moisture, per the manufacturer recommendations.

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